Danazol (Danazol)

This medication is a synthetic hormone. It is used to treat pain and infertility caused by endometriosis, a condition involving the tissue of the uterus. It is also used in the treatment of cysts or lumps in the breast or may be prescribed for heavy menstrual flow.

This medication must be taken as directed. Follow your dosing schedule carefully. You must take for full length of therapy. You may be asked to visit your doctor regularly to make sure the drug is working properly. Usual treatment starts with 100mg three times a day. Increase to 200mg three times a day if tolerated. Watch blood pressure, liver function tests and blood sugar levels.

Danazol is a synthetic androgen (male sex hormone.) It disrupts the action of the pituitary gland by suppressing the output of some hormones which causes the reduction of estrogen, halts menses and promotes the growth of facial hair and acne. Danazol is considered a second line treatment. The response rate has been about 30%. (Ref 1).

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Store at room temperature away from sunlight and moisture.

Danazol must not be used during pregnancy. It is recommended a pregnancy test to be performed before starting use of this drug. Effective, non-hormonal birth control measures (such as diaphragms and condoms) should be used while using danazol. Danazol may cause heart or circulation problems (blood clots), liver problems or increase pressure on the brain. Notify your doctor immediately if you develop any of the following: one-sided weakness, sudden vision changes, slurred speech, arm or leg pain, breathing trouble, chest pain, yellowing eyes/skin, dark urine, dizziness, fainting, swelling, stomach pain, head pain.While you take danazol, tell your doctor if you have: migraine headaches, heart disease, liver disease, kidney disease, seizures, breast cancer, abnormal bleeding, strokes, prostate cancer, other illnesses, allergies (especially drug allergies). If dizziness or blurred vision occurs, use caution engaging in activities, requiring alertness. Extreme caution is advised for use in children. Pediatric specialist consultation is also advised. Geriatric men are at the increased risk of developing the enlarged prostate and prostate cancer with the use of androgen-like drugs. Use of non-hormonal contraceptives such as a condom, diaphragm or sponge is recommended while taking this drug and until you have had at least one menstrual period after stopping the drug. Danazol can cause menstrual periods to stop entirely but they usually resume within two to three months after danazol treatment. This drug must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Breast feeding should be avoided while using this drug.